Pathophysiological Mechanisms, Risk Factors for Disease Development and Progression, and Therapeutic Targets
نویسندگان
چکیده
.37. Boileau C, Martel-Pelletier J, Brunet J, et al. Oral treatment with PD-0200347, anα2δ ligand, reduces the development ofexperimental osteoarthritis by inhibiting metalloproteinases and inducible nitric oxide synthase gene expression and synthesis in cartilage chondrocytes. Arthritis Rheum. 2005 Feb;52(2):488-500.38. Pelletier JP, Lascau-Coman V, Jovanovic D, et al. Selective inhibition of inducible nitric oxide synthase in experimental osteoarthritis is associated with reduction in tissue levels of catabolic factors. J Rheumatol. 1999 Sep;26(9):2002-14. Bulletin of the NYU Hospital for Joint Diseases 2007;65(3):242-8248 39. Pelletier JP, Jovanovic DV, Lascau-Coman V, et al. Selectiveinhibition of inducible nitric oxide synthase reduces progres-sion of experimental osteoarthritis in vivo: possible link withthe reduction in chondrocytes apoptosis and caspase 3 level.Arthritis Rheum. 2000;43:1290-9.40. Renkiewicz R, Qiu L, Lesch C, et al. Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculosk-eletal side effects in rats. Arthritis Rheum. 2003;48(6):1742-9.41. Manicourt DH, Altman RD, Williams JM, et al. Treatment with calcitonin suppresses the responses of bone, cartilage,and synovium in the early stages of canine experimentalosteoarthritis and significantly reduces the severity of thecartilage lesions. Arthritis Rheum. 1999 Jun;42(6):1159-67.42. Hayami T, Pickarski M, Wesolowski GA, et al. The role of subchondral bone remodeling in osteoarthritis: reduction ofcartilage degeneration and prevention of osteophyte formationby alendronate in the rat anterior cruciate ligament transectionmodel. Arthritis Rheum. 2004 Apr;50(4):1193-206.43. Pelletier JP, Boileau C, Brunet J, et al. The inhibition of sub-chondral bone resorption in the early phase of experimentaldog osteoarthritis by licofelone is associated with a reductionin the synthesis of MMP-13 and cathepsin K. Bone. 2004Mar;34(3):527-38.
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